Benefits of β-glucans in patients with breast cancer: systematic literature review

Authors

  • Carolina Trabasso Ferraz de Oliveira Universidade Santo Amaro (UNISA), São Paulo, SP
  • Giovanna Seto de Oliveira Universidade Federal de São Paulo (UNIFESP), São Paulo, SP
  • Hezio Jadir Fernandes Junior Fernandes Junior Universidade Federal de São Paulo (UNIFESP), São Paulo, SP
  • Fernando Sabia Tallo Department of Clinical Medicine - UNIFESP, São Paulo, SP
  • Afonso Caricati-Neto Department of Pharmacology - UNIFESP, São Paulo, SP
  • Junaid Tantray Department of Pharmacy, NIMS University, Jaipur, Rajasthan
  • Bianca Lorayne de Almeida Viana Universidade Santo Amaro (UNISA), São Paulo, SP
  • Francisco Sandro Menezes Rodrigues Universidade Federal de São Paulo (UNIFESP), São Paulo, SP

DOI:

https://doi.org/10.37497/JMRReview.v3i00.58

Keywords:

β-glucans, Breast cancer, benefits of β-glucans, modulation of the immune system, nutraceutical

Abstract

Breast cancer is the most prevalent cancer, totaling 50 thousand new cases per year, as well as being responsible for a high annual mortality rate. Some preventive measures are simple and easy to carry out, such as practicing physical activities, eating a healthy diet, not smoking, avoiding drinking alcohol, carrying out self-examinations and mammograms frequently. Several recent studies have demonstrated that the consumption of nutraceuticals rich in beta-glucans (β-glucans) can have a positive impact on both the prevention and treatment of breast cancer. β-glucans are natural polysaccharides found in the cell walls of fungi and yeast that promote the stimulation of cells that make up the immune system and modulation of tumor cells.

Author Biographies

Carolina Trabasso Ferraz de Oliveira, Universidade Santo Amaro (UNISA), São Paulo, SP

School of Medicine, Universidade Santo Amaro (UNISA), São Paulo, SP – Brazil

Giovanna Seto de Oliveira, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP

Postgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP – Brazil.

Hezio Jadir Fernandes Junior Fernandes Junior, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP

Postgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP – Brazil

Fernando Sabia Tallo, Department of Clinical Medicine - UNIFESP, São Paulo, SP

Department of Clinical Medicine - UNIFESP, São Paulo, SP – Brazil

Afonso Caricati-Neto, Department of Pharmacology - UNIFESP, São Paulo, SP

Department of Pharmacology - UNIFESP, São Paulo, SP – Brazil

Junaid Tantray, Department of Pharmacy, NIMS University, Jaipur, Rajasthan

Department of Pharmacy, NIMS University, Jaipur, Rajasthan - India

Bianca Lorayne de Almeida Viana, Universidade Santo Amaro (UNISA), São Paulo, SP

School of Medicine, Universidade Santo Amaro (UNISA), São Paulo, SP – Brazil

Francisco Sandro Menezes Rodrigues, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP

Postgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP – Brazil.  And Postgraduate Program in in Interdisciplinary Surgical Science - UNIFESP, São Paulo, SP.

References

Jamal-Hanjani, M.; Wilson, G. A.; McGranahan, N.; Birkbak, N. J.; Watkins, T.; Veeriah, S.; Shafi, S.; Johnson, D. H.; Mitter, T.; Rosenthal, R.; Salm, M.; Horswell, S.; Escudero, M.; Matthews, N.; Rowan, A.; Chambers, T.; Moore, D. A.; Turajlic, S.; Xu, H.; Lee, S. M., … TRACERx Consortium. Tracking the evolution of non-small-cell lung cancer. New England Journal of Medicine 2017, 376, 2109-2121.

Sagar, B.; Lin, Y.S.; Castel, L.D. Cost drivers for breast, lung, and colorectal cancer care in a commercially insured population over a 6-month episode: an economic analysis from a health plan perspective. Journal of Medical Economics 2017, 20, 1018–1023.

Morigi, C. Highlights from the 15th St Gallen International Breast Cancer Conference, Vienna: tailored treatments for patients with early breast cancer. Ecancermedicalscience 2017, 11, 732.

Carling, D. AMPK signalling in health and disease. Current Opinion in Cell Biology 2017, 45, 31–37.

Errante, P.R.; Neto, A.C.; Bergantin, L. B. Insights for the inhibition of cancer progression: Revisiting Ca2+ and cAMP signalling pathways. Advances in Cancer Prevention 2017, 2, e103.

Yap, H. Y. Y.; Tan, N. H.; Ng, S. T.; Tan, C. S.; Fung, S. Y. Molecular attributes and apoptosis-inducing activities of a putative serine protease isolated from Tiger Milk mushroom (Lignosus rhinocerus) sclerotium against breast cancer cells in vitro. PeerJ 2018, e4940.

Gebrim, L. H.; Quadros, L. G. A. Breast cancer screening in Brazil. Rev Bras Ginecol Obstet 2006, 319-326.

Corso, C. R.; Oliveira, N. M. T.; Cordeiro, L. M.; Silva, K. S.; Soczek, S. H.; Rossato, V. F.; Fernandes, E. S.; Maria-Ferreira, D. Polysaccharides with antitumor effect in breast cancer: a systematic review of non-clinical studies. Nutrients 2021.

Usuldin, S. R. A.; Mahmud, N.; Ilham, Z.; Ikram, N. K. K.; Ahmad, R.; Wan-Mohtar, W. A. Q. I. In-depth spectral characterization of antioxidative (1,3)-β-D-glucan from the mycelium of an identified tiger milk mushroom Lignosus rhinocerus strain ABI in a stirred-rank bioreactor. Biocatalysis and Agricultural Biotechnology 2020.

Jafaar, Z. M.; Litchfield, L. M.; Ivanova, M. M.; Radde, B. N.; Al-Rayyan, N.; Klinge, C. M. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol 2014, 4, 1365-1375.

Wani, S. M.; Gani, A.; Mir, S. A.; Masoodi, F. A.; Khanday, F. A. β-glucan: a dual regulator of apoptosis and cell proliferation. Int J Biol Macromol 2021, 1229-1237.

Akramiene, D.; Kondrotas, A.; Didziapetriene, J.; Kevelaitis, E. Effects of β-glucans on the immune system. Medicina (Kaunas) 2007, 8, 597-606.

Chan, G. C.; Chan, W. K.; Sze, D. M. The effects of β-glucans on human immune and cancer cells. J Hematol Oncol 2009.

Chilhara, G. Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Dev Biol Stand 1992, 77, 191-197.

Gu, S.; Xu, J.; Teng, W.; Huang, X.; Mei, H.; Chen, X.; Nie, G.; Cui, Z.; Liu, X.; Zhang, Y.; Wang, K. Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence. Int J Biol Macromol 2022.

Hu, T.; Huang, Q.; Wong, K.; Yang, H. Structure, molecular conformation, and immunomodulatory activity of four polysaccharide fractions from Lignosus rhinocerotis sclerotia. Int J Biol Macromol 2017, 94, 423-430.

Jiang, J.; Silva, D. Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells. Int J Oncol 2010, 6, 1529-1536.

Luca, F.; Roda, E.; Ratto, D.; Desiderio, A.; Venuti, M. T.; Ramieri, M.; Bottone, M. G.; Savino, E.; Rossi, P. Fighting secondary triple-negative breast cancer in cerebellum: a powerful aid from a medicinal mushrooms blend. Biomed Pharmacother 2023.

Ostadrahimi, A.; Esfahani, A.; Jafarabadi, M. A.; Ziaei, J. E.; Movassaghpourakbari, A.; Farrin, N. Effect of beta glucan on quality of life in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial. Adv Pharm Bull 2014, 4, 471-477.

Rutckeviski, R.; Corso, C. R.; Román-Ochoa, Y.; Cipriani, T. R.; Centa, A.; Smiderle, F. R. Agaricus bisporus β-(1-6)-D-glucan induces M1 phenotype on macrophages and increases sensitivity to doxorubicin of triple negative breast cancer cells. Carbohydr Polym 2022.

Shui, Y.; Hu, X.; Hirano, H.; Kusano, K.; Tsukamoto, H.; Li, M.; Hasumi, K.; Guo, W. Z.; Li, X. K. β-glucan from Aureobasidium pullulans auguments the anti-tumor immune responses through activated tumor-associated dendritic cells. Int Immunopharmacol 2021.

Vetvicka, A. V.; Vetvickova, J. Combination of glucan, Resveratrol and vitamin C demonstrates strong anti-tumor potential. Anticancer Res 2012, 1, 81-87.

Zhang, X.; Li, T.; Liu, S.; Xu, Y.; Meng, M.; Li, X.; Lin, Z.; Wu, Q.; Xue, Y.; Pan, Y.; Alitongbieke, G. β-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1α axis. Biosci Rep 2020.

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Published

2024-04-23

How to Cite

Ferraz de Oliveira, C. T., Seto de Oliveira, G., Fernandes Junior, H. J. F. J., Tallo, F. S., Caricati-Neto, A., Tantray, J., Viana, B. L. de A., & Rodrigues, F. S. M. (2024). Benefits of β-glucans in patients with breast cancer: systematic literature review. Journal of Medical Residency Review, 3(00), e058. https://doi.org/10.37497/JMRReview.v3i00.58

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