Silicone implants and development of autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA): integrative literature review
DOI:
https://doi.org/10.37497/JMRReview.v3i00.60Keywords:
Silicone prostheses, Breast implants, Autoimmune reactions, Plastic surgeryAbstract
Background: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) is an emerging condition associated with components such as silicone in breast implants, which provokes a chronic inflammatory response and can trigger autoimmune diseases. Although the exact mechanisms of ASIA are still being investigated, the condition manifests itself with varied symptoms, such as chronic fatigue, arthralgias and neurological symptoms, making diagnosis and management difficult.
Aim: Through an integrative literature review, to evaluate the development of ASIA caused by silicone implants.
Method: This is an exploratory study based on the literature review method with evidence synthesis. The database chosen to select the papers was PUBMED, using the following search strategy: (asia[title] OR (autoimmune[title] OR inflammatory[title])) AND syndrome[title] AND silicon*[title]. Studies published in the last decade were evaluated, and any paper that discussed the proposed topic was initially included in the sample.
Results: Initially, 12 studies were identified which met the search strategy mentioned above. After reading the titles and abstracts, 2 papers were excluded because they did not discuss the proposed topic, leaving 10 studies that made up the final sample for the review.
Conclusion: The papers analyzed highlight that ASIA, especially in patients with silicone implants, is associated with a wide range of systemic and autoimmune symptoms, significantly impacting the quality of life of affected individuals. Evidence suggests a correlation between exposure to silicone and the development of autoimmune conditions, reinforcing the importance of including ASIA in the differential diagnosis in cases of non-specific symptoms. This reinforces the need for greater awareness and research to identify risk factors and effective management strategies.
References
AGUILERA-FERNANDEZ, P. et al. The “autoimmune/inflammatory syndrome induced by adjuvants” (ASIA) after COVID-19 infection: A case report. Reumatología Clínica (English Edition), v. 19, n. 10, p. 593–595, 1 dez. 2023.
BARILARO, G. et al. ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review. Immunologic Research, v. 64, n. 5–6, p. 1142–1149, dez. 2016.
BECERRA-GONZALES, V. G. et al. Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) after a silicone injection. BMJ case reports, v. 13, n. 3, p. e234832, 31 mar. 2020.
COHEN TERVAERT, J. W. et al. Breast implant illness: scientific evidence of its existence. Expert review of clinical immunology, v. 18, n. 1, p. 15–29, 2022.
COHEN TERVAERT, J. W. et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023. Autoimmunity Reviews, v. 22, n. 5, p. 103287, maio 2023.
COLARIS, M. J. L. et al. Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature. Immunologic Research, v. 65, n. 1, p. 120–128, fev. 2017.
DE CARVALHO, J. F. et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) with postural orthostatic tachycardia syndrome after silicone breast implantation: Case report. European Journal of Rheumatology, v. 10, n. 1, p. 23–25, jan. 2023.
HERRERO-RUIZ, S. P. et al. A case of systemic lupus erythematosus in the context of ASIA syndrome because of silicone breast implants. International Journal of Dermatology, v. 62, n. 12, p. 1549–1550, dez. 2023.
KAPPEL, R. M.; COHEN TERVAERT, J. W.; PRUIJN, G. J. M. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) due to silicone implant incompatibility syndrome in three sisters. Clinical and Experimental Rheumatology, v. 32, n. 2, p. 256–258, 2014.
KATSNELSON, J. Y. et al. Outcomes of Implant Removal and Capsulectomy for Breast Implant Illness in 248 Patients. Plastic and Reconstructive Surgery – Global Open, v. 9, n. 9, p. e3813, set. 2021.
MALDONADO, G. et al. Autoinflammatory/Autoimmunity Syndrome Induced By Adjuvants (ASIA) Due to Silicone Incompatibility Syndrome. Case Reports in Rheumatology, v. 2021, p. 5595739, 2021.
NESHER, G. et al. Severe ASIA syndrome associated with lymph node, thoracic, and pulmonary silicone infiltration following breast implant rupture: experience with four cases. Lupus, v. 24, n. 4–5, p. 463–468, abr. 2015.
NUNES E SILVA, D. et al. Autoimmune Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Augmentation Surgery. Plastic and Reconstructive Surgery. Global Open, v. 5, n. 9, p. e1487, set. 2017.
PAVLOV-DOLIJANOVIC, S.; VUJASINOVIC STUPAR, N. Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants: description of three patients and a critical review of the literature. Rheumatology International, v. 37, n. 8, p. 1405–1411, ago. 2017.
POSSO-OSORIO, I. et al. Hepatic infiltration by silicone in a patient With ASIA syndrome. Hepatology (Baltimore, Md.), v. 67, n. 1, p. 444–445, jan. 2018.
SEIDA, I. et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications. Clinical and Experimental Immunology, v. 213, n. 1, p. 87–101, 5 jul. 2023.
SHOENFELD, Y.; AGMON-LEVIN, N. ‘ASIA’ – Autoimmune/inflammatory syndrome induced by adjuvants. Journal of Autoimmunity, v. 36, n. 1, p. 4–8, 1 fev. 2011.
SORIANO, A.; BUTNARU, D.; SHOENFELD, Y. Long-term inflammatory conditions following silicone exposure: the expanding spectrum of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Clinical and Experimental Rheumatology, v. 32, n. 2, p. 151–154, 2014.
VAN DER PLUIJM, R. W. et al. Immune reconstitution inflammatory syndrome induced by gluteal silicones in a transgender woman living with HIV. International journal of STD & AIDS, v. 33, n. 6, p. 625–627, maio 2022.
WEE, C. E. et al. Understanding Breast Implant Illness, Before and After Explantation: A Patient-Reported Outcomes Study. Annals of Plastic Surgery, v. 85, n. S1, p. S82, jul. 2020.
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