Major depressive episode with psychotic symptoms and difficulty to access electroconvulsive therapy resulting in prolonged hospitalization: a case report

Authors

  • Angelo Victor Maciel Lima Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP
  • Regina Caeli Guerra Poças Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP

DOI:

https://doi.org/10.37497/JMRReview.v2i1.30

Keywords:

Psychiatry, Major Depressive Disorder, Psychosis, Psychotic Depression, Electroconvulsive Therapy

Abstract

Aim: To report a case of a patient with severe depressive episode and psychotic symptoms that, that due to difficulty in accessing ECT, led to prolonged hospitalization of the patient.

Method: This is a patient treated at the Psychiatry Service of the Hospital Universitário São Francisco na Providência de Deus – HUSF, located in the city of Bragança Paulista – SP, Brazil.

Case Report: It was a male patient, 57 years old, retired, with symptoms of social isolation, anhedonia, weight loss and intense decrease in fluid intake. He had mixed delirium, inappetence and sleep disorders, being referred to a specialized Hospital after worsening with the initial treatment. Due to her prolonged hospitalization and poor response to treatment (initially with citalopram, levomepromazine and quetiapine), the psychiatry team requested her transfer to a Hospital with ECT, but without success. During hospitalization, the therapeutic regimen was changed to a combination of venlafaxine and quetiapine, the latter being subsequently replaced by risperidone. There was gradual improvement of the condition, with weight gain and discharge after 53 days. In the post-discharge follow-up, the condition was stable and the medication was regularly used, with full return of functionality.

Conclusion: If available, ECT can be a great tool for the treatment of severe depressive episodes, especially with associated psychotic symptoms, mainly in patients with resistance to pharmacological treatments. Its use tends to reduce the length of hospital stay and restore quality of life to patients. The case presented in this paper is a specific example of how the absence of ECT caused an increase in the hospitalization time of a patient with psychotic depression, affecting his routine and quality of life, in addition to generating costs resulting from the provoked hospitalization.

Author Biographies

Angelo Victor Maciel Lima, Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP

Serviço de Psiquiatria. Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP.

Regina Caeli Guerra Poças, Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP

Serviço de Psiquiatria. Hospital Universitário São Francisco na Providência de Deus – HUSF. Bragança Paulista - SP

References

ALI, S. A. et al. Electroconvulsive Therapy and Schizophrenia: A Systematic Review. Molecular Neuropsychiatry, v. 5, n. 2, p. 75–83, abr. 2019. DOI: https://doi.org/10.1159/000497376

AMERICAN PSYCHIATRIC ASSOCIATION, D.; ASSOCIATION, A. P. Diagnostic and statistical manual of mental disorders: DSM-5. American psychiatric association Washington, DC, 2013. v. 5 DOI: https://doi.org/10.1176/appi.books.9780890425596

BROMET, E. et al. Cross-national epidemiology of DSM-IV major depressive episode. BMC medicine, v. 9, p. 90, 26 jul. 2011. DOI: https://doi.org/10.1186/1741-7015-9-90

DE AQUINO, J. P.; LONDONO, A.; CARVALHO, A. F. An update on the epidemiology of major depressive disorder across cultures. Understanding Depression: Volume 1. Biomedical and Neurobiological Background, p. 309–315, 2018. DOI: https://doi.org/10.1007/978-981-10-6580-4_25

DE SMET, C. J.; SABBE, B.; OLDENBURG, J. F. E. The Effect of Electroconvulsive Therapy on Hypoperfusion in Psychotic Bipolar Depression: A Case Study. The journal of ECT, v. 34, n. 2, p. 124–126, jun. 2018. DOI: https://doi.org/10.1097/YCT.0000000000000487

DUBOVSKY, S. L. et al. Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment. Psychotherapy and Psychosomatics, v. 90, n. 3, p. 160–177, 2021. DOI: https://doi.org/10.1159/000511348

FLINT, A. J. et al. Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD ΙΙ. BMC Psychiatry, v. 13, n. 1, p. 38, 25 jan. 2013. DOI: https://doi.org/10.1186/1471-244X-13-38

GLOBAL BURDEN OF DISEASE STUDY 2013 COLLABORATORS. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (London, England), v. 386, n. 9995, p. 743–800, 22 ago. 2015.

HEIM, C.; BINDER, E. B. Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Experimental Neurology, v. 233, n. 1, p. 102–111, jan. 2012. DOI: https://doi.org/10.1016/j.expneurol.2011.10.032

HERMIDA, A. P. et al. Electroconvulsive Therapy in Depression: Current Practice and Future Direction. The Psychiatric Clinics of North America, v. 41, n. 3, p. 341–353, set. 2018. DOI: https://doi.org/10.1016/j.psc.2018.04.001

HIRSCHFELD, R. M. A. The epidemiology of depression and the evolution of treatment. The Journal of Clinical Psychiatry, v. 73 Suppl 1, p. 5–9, 2012. DOI: https://doi.org/10.4088/JCP.11096su1c.01

HOWELLS, D. et al. Electroconvulsive Therapy Reverses Cerebral Hypoperfusion in a Patient With Psychotic Depression and Catatonia. The journal of ECT, v. 38, n. 2, p. 141–143, 1 jun. 2022. DOI: https://doi.org/10.1097/YCT.0000000000000836

KALIORA, S. C.; ZERVAS, I. M.; PAPADIMITRIOU, G. N. Electroconvulsive therapy: 80 years of use in psychiatry. Psychiatrike = Psychiatriki, v. 29, n. 4, p. 291–302, 2018. DOI: https://doi.org/10.22365/jpsych.2018.294.291

KESSLER, R. C. et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, v. 62, n. 6, p. 593–602, jun. 2005. DOI: https://doi.org/10.1001/archpsyc.62.6.593

KESSLER, R. C.; BROMET, E. J. The epidemiology of depression across cultures. Annual Review of Public Health, v. 34, p. 119–138, 2013. DOI: https://doi.org/10.1146/annurev-publhealth-031912-114409

KUEHNER, C. Why is depression more common among women than among men? The Lancet. Psychiatry, v. 4, n. 2, p. 146–158, fev. 2017. DOI: https://doi.org/10.1016/S2215-0366(16)30263-2

MALHI, G. S. et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders: major depression summary. The Medical Journal of Australia, v. 208, n. 4, p. 175–180, 5 mar. 2018. DOI: https://doi.org/10.5694/mja17.00659

MALHI, G. S.; MANN, J. J. Depression. Lancet (London, England), v. 392, n. 10161, p. 2299–2312, 24 nov. 2018. DOI: https://doi.org/10.1016/S0140-6736(18)31948-2

MONROE, S. M.; HARKNESS, K. L. Major Depression and Its Recurrences: Life Course Matters. Annual Review of Clinical Psychology, v. 18, p. 329–357, 9 maio 2022. DOI: https://doi.org/10.1146/annurev-clinpsy-072220-021440

MORA, C. et al. Blood biomarkers and treatment response in major depression. Expert Review of Molecular Diagnostics, v. 18, n. 6, p. 513–529, jun. 2018. DOI: https://doi.org/10.1080/14737159.2018.1470927

NESTLER, E. J.; HYMAN, S. E. Animal models of neuropsychiatric disorders. Nature Neuroscience, v. 13, n. 10, p. 1161–1169, out. 2010. DOI: https://doi.org/10.1038/nn.2647

NORMARK, S.; GBYL, K.; VIDEBECH, P. Continuation electroconvulsive therapy for depression. Ugeskrift for Laeger, v. 183, n. 51, p. V05210435, 20 dez. 2021.

RASK, O. et al. Electroconvulsive therapy for manic state with mixed and psychotic features in a teenager with bipolar disorder and comorbid episodic obsessive-compulsive disorder: a case report. Journal of Medical Case Reports, v. 11, n. 1, p. 345, 12 dez. 2017. DOI: https://doi.org/10.1186/s13256-017-1508-8

ROTHSCHILD, A. J. Challenges in the treatment of major depressive disorder with psychotic features. Schizophrenia Bulletin, v. 39, n. 4, p. 787–796, jul. 2013. DOI: https://doi.org/10.1093/schbul/sbt046

VAN ROOIJEN, G. et al. Treating depressive episodes or symptoms in patients with schizophrenia. CNS spectrums, v. 24, n. 2, p. 239–248, abr. 2019. DOI: https://doi.org/10.1017/S1092852917000554

VOS, T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (London, England), v. 380, n. 9859, p. 2163–2196, 15 dez. 2012.

WORLD HEALTH ORGANIZATION (WHO). International Statistical Classification of Diseases and related health problems: Alphabetical index. World Health Organization, 2004. v. 3.

WORLD HEALTH ORGANIZATION (WHO). International classification of diseases for mortality and morbidity statistics (11th Revision). , 2018.

YRONDI, A. et al. Electroconvulsive therapy, depression, the immune system and inflammation: A systematic review. Brain Stimulation, v. 11, n. 1, p. 29–51, 2018. DOI: https://doi.org/10.1016/j.brs.2017.10.013

Published

2023-08-08

How to Cite

Lima, A. V. M., & Poças, R. C. G. (2023). Major depressive episode with psychotic symptoms and difficulty to access electroconvulsive therapy resulting in prolonged hospitalization: a case report. Journal of Medical Residency Review, 2(1), e030. https://doi.org/10.37497/JMRReview.v2i1.30

Issue

Section

Relato de caso